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USE OF L. REUTERI FOR RECOVERY OF MICROBIOTA DYSBIOSIS IN EARLY LIFE

机译:金黄色葡萄球菌用于早期生命中的细菌性痢疾的恢复

摘要

The invention concerns Lactobacillus reuteri for use in the prevention or treatment of microbiota dysbiosis, in particular, decreased levels of Actinobacteria and increased levels of Proteobacteria, in young mammals and in the prevention or treatment of disorders associated therewith. The microbiota dysbiosis may have been cause by numerous factors including being born by caesarean section, exposure to antibiotics in utero or after birth, or, parenteral feeding, hospitalizing, psychological stress or by gastrointestinal dysfunctions. The disorders that may be treated or prevented by preventing or treating microbiota dysbiosis include propensity to infection, allergy, type I diabetes mellitus, insulin resistance, type 2 diabetes, celiac disease, peripheral and central adiposity, obesity, necrotizing enterocolitis, inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, and functional gastrointestinal disorders such as IBS, functional diarrhea, functional constipation, recurrent abdominal pain, and dyspepsia.
机译:本发明涉及在年轻哺乳动物中用于预防或治疗微生物群失调的罗伊氏乳杆菌,特别是放线菌水平的降低和变形杆菌水平的提高,以及用于预防或治疗与其相关的疾病。微生物群失调可能是由多种因素引起的,包括因剖腹产而出生,子宫内或出生后暴露于抗生素,或者肠胃外进食,住院,心理压力或胃肠道功能障碍。可以通过预防或治疗微生物群失调来治疗或预防的疾病包括感染倾向,过敏,I型糖尿病,胰岛素抵抗,2型糖尿病,乳糜泻,周围和中央肥胖,肥胖,坏死性小肠结肠炎,炎性肠病,如克罗恩氏病和溃疡性结肠炎,以及功能性胃肠道疾病如IBS,功能性腹泻,功能性便秘,反复发作的腹痛和消化不良。

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