首页> 外国专利> USE OF RANK/RANKL ANTAGONISTS FOR TREATING NEUROMUSCULAR DISORDERS, GENETIC MYOPATHIES AND/OR NON GENETIC MYOPATHIES AND/OR FOR REGULATING SKELETAL AND CARDIAC MUSCLE DISUSE, DISEASES AND AGING

USE OF RANK/RANKL ANTAGONISTS FOR TREATING NEUROMUSCULAR DISORDERS, GENETIC MYOPATHIES AND/OR NON GENETIC MYOPATHIES AND/OR FOR REGULATING SKELETAL AND CARDIAC MUSCLE DISUSE, DISEASES AND AGING

机译：使用RANK / RANKL拮抗剂治疗神经肌肉疾病，遗传肌病和/或非遗传肌病和/或调节骨骼肌和心脏肌肉的失调，疾病和衰老

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摘要

The present invention relates to uses and methods comprising one or more RANK/RANKL antagonists or of a pharmaceutical composition comprising one or more RANK/RANKL antagonists and a pharmaceutically acceptable carrier for treating neuromuscular disorders, non-genetic myopathies, or genetic myopathies; maintaining and/or preserving the excitation:contraction:relaxation coupling; reducing loss of muscle strength associated with neuromuscular disorders, non-genetic myopathies or genetic myopathies; reducing the loss of muscular strength associated with skeletal or cardiac muscle disuse, diseases and aging; or regulating skeletal or cardiac muscle disuse, diseases and/or aging in a patient in need thereof. The present invention also relates to combinations and compositions comprising one or more RANK/RANKL antagonists and to methods for identifying candidate compounds.

机译：本发明涉及用于治疗神经性肌肉疾病，非遗传性肌病或遗传性肌病的包含一种或多种RANK / RANKL拮抗剂或包含一种或多种RANK / RANKL拮抗剂和药学上可接受的载体的药物组合物的用途和方法;保持和/或保持激发：收缩：松弛耦合;减少与神经肌肉疾病，非遗传性肌病或遗传性肌病有关的肌肉力量损失;减少与骨骼或心肌废用，疾病和衰老相关的肌肉力量损失;或调节有需要的患者的骨骼或心肌废用，疾病和/或衰老。本发明还涉及包含一种或多种RANK / RANKL拮抗剂的组合和组合物，以及鉴定候选化合物的方法。

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公开/公告号US2018064810A1

专利类型
公开/公告日2018-03-08

原文格式PDF
申请/专利权人 UNIVERSITÉ LAVAL;
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申请/专利号US201715701317
发明设计人 JÉRÔME FRENETTE;JOSEF PENNINGER;
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申请日2017-09-11
分类号A61K39/395;A61K31/7105;A61K38/30;A61K45/06;C12N15/113;A61K38/17;A61K31/675;A61K31/573;A61K31/55;A61K31/472;A61K31/417;A61K31/405;A61K31/403;A61K31/401;A61K31/167;A61K31/137;A61K31/568;G01N33/68;A61K38/27;
国家 US
入库时间 2022-08-21 12:59:49

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