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Method of producing personalized biomimetic drug-eluting coronary stents by 3D-printing

机译:通过3D打印生产个性化仿生药物洗脱冠状动脉支架的方法

摘要

A method for using 3D printing technology produces personalized biomimetic drug-eluting coronary stent and the product thereof. The process of manufacturing stent, based on coronary angiography imaging data, measures the diameter of diseased coronary and conducts 3D reconstruction. A personalized stent for each patient according to diameter, length, and morphological characteristics of target vessel that suited to the lesion is produced. The coronary stent is formed from biodegradable poly-L-lactic acid (PLLA) or other materials. The stent is modeled by 3D printing and then coated with polymers carrying antiproliferative drug to reduce restenosis (the polymers is a mixture of antiproliferative drug and PDLLA at a ratio of 1:1). The biomimetic drug-eluting coronary stent produced by 3D printing technology is personalized stent for each patient according to different characteristics of diseased coronary, reduces the incidence of vascular injury, thrombosis, dissection and other complications caused by stent and vessel diameter mismatch.
机译:使用3D打印技术的方法可生产个性化仿生药物洗脱冠状动脉支架及其产品。根据冠状动脉造影图像数据制造支架的过程,可测量患病冠状动脉的直径并进行3D重建。根据直径,长度和适合病变的目标血管的形态特征,为每位患者提供个性化的支架。冠状动脉支架由可生物降解的聚L-乳酸(PLLA)或其他材料形成。通过3D打印对支架建模,然后用携带抗增殖药以减少再狭窄的聚合物包被(聚合物是抗增殖药和PDLLA的比例为1:1的混合物)。通过3D打印技术生产的仿生药物洗脱冠状动脉支架是针对每个患者的个性化支架,可根据患病冠状动脉的不同特征,减少因支架和血管直径不匹配而引起的血管损伤,血栓形成,解剖和其他并发症的发生。

著录项

  • 公开/公告号US9943627B2

    专利类型

  • 公开/公告日2018-04-17

    原文格式PDF

  • 申请/专利权人 YUJIE ZHOU;WEI SUN;QIAN MA;LEI ZHANG;

    申请/专利号US201514743782

  • 发明设计人 YUJIE ZHOU;WEI SUN;QIAN MA;LEI ZHANG;

    申请日2015-06-18

  • 分类号A61L31/16;A61F2/82;A61L31/10;A61L31/14;B33Y80;B33Y70;A61L31/06;A61B90;B29C64/106;B29C64/153;B33Y10;B33Y30;B33Y50/02;B29K67;

  • 国家 US

  • 入库时间 2022-08-21 12:59:51

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