首页> 外国专利> COMPOSITION FOR ANTICANCER ADJUVANT COMPRISING RIP3 EXPRESSION PROMOTER AS ACTIVE INGREDIENT, METHOD FOR SCREENING ANTICANCER ADJUVANT WHICH PROMOTES RIP3 EXPRESSION AND ENHANCES SENSITIVITY OF ANTICANCER AGENT, AND METHOD FOR MONITORING SENSITIVITY OF ANTICANCER AGENT

COMPOSITION FOR ANTICANCER ADJUVANT COMPRISING RIP3 EXPRESSION PROMOTER AS ACTIVE INGREDIENT, METHOD FOR SCREENING ANTICANCER ADJUVANT WHICH PROMOTES RIP3 EXPRESSION AND ENHANCES SENSITIVITY OF ANTICANCER AGENT, AND METHOD FOR MONITORING SENSITIVITY OF ANTICANCER AGENT

机译：包含RIP3表达促进剂作为活性成分的抗癌剂组合物，筛选促进RIP3表达并增强抗癌剂敏感性的抗癌剂佐剂的方法以及监测抗癌剂敏感性的方法

页面导航

摘要
著录项
相似文献

摘要

The present invention relates to a pharmaceutical composition for an anticancer adjuvant comprising a receptor-interacting protein kinase-3 (RIP3) protein expression promotor or activator as an active ingredient. In addition, the present invention provides a method of promoting cancer cell apoptosis, characterized by co-administering an anticancer agent and a RIP3 protein expression promotor or activator to cancer cells. Also, the present invention relates to a method for screening an anticancer adjuvant which promotes RIP3 expression and enhances sensitivity of an anticancer agent, and a method for monitoring sensitivity of an anti-cancer agent depending on the RIP3 expression. Accordingly, in the case of a patient lacking the expression of RIP3, it is expected to be an effective treatment strategy to pre-treat a demethylating agent to induce the expression of RIP3 and then to use a conventional chemotherapeutic agent. In addition, in chemotherapy, it is anticipated that the present invention may be an effective strategy in screening an anticancer adjuvant which monitors and enhances sensitivity of an anticancer agent.

机译：本发明涉及用于抗癌佐剂的药物组合物，其包含受体相互作用蛋白激酶3（RIP3）蛋白表达促进剂或激活剂作为活性成分。另外，本发明提供了促进癌细胞凋亡的方法，其特征在于将抗癌剂和RIP3蛋白表达促进剂或活化剂共同施用给癌细胞。另外，本发明涉及用于筛选促进RIP3表达并增强抗癌剂敏感性的抗癌佐剂的方法，以及根据RIP3表达来监测抗癌剂敏感性的方法。因此，在患者缺乏RIP3表达的情况下，预期是预处理脱甲基剂以诱导RIP3表达然后使用常规化学治疗剂的有效治疗策略。另外，在化学疗法中，预期本发明可以是筛选监测和增强抗癌剂敏感性的抗癌佐剂的有效策略。

著录项

公开/公告号US2018231553A1

专利类型
公开/公告日2018-08-16

原文格式PDF
申请/专利权人 AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;
展开▼

申请/专利号US201615750421
发明设计人 YOU-SUN KIM;GI BANG KOO;
展开▼

申请日2016-05-07
分类号G01N33/574;A61K38/45;A61K47/66;A61P35;
国家 US
入库时间 2022-08-21 13:00:36

相似文献

专利
外文文献
中文文献