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Methods of Screening for Drugs to Prevent Noise-Induced Hearing Loss

机译:预防噪声引起的听力损失的药物筛查方法

摘要

The invention relates to methods of identifying a composition useful for the prevention or treatment of noise-induced hearing loss. The method includes exposing a mammalian test subject to a candidate composition and a calibrated sound or noise challenge. Next, a temporary threshold shift (TTS) is monitored in the test subject over a period of time. The monitored TTS is compared with a TTS of a control subject exposed to a control composition. The presence or absence is determined by clinically relevant and statistically significant differences between the monitored TTS in the test subject and the TTS of the control subject, and the presence of a statistically significant difference identifies the candidate composition as useful for prevention or treatment of noise-induced hearing loss.
机译:本发明涉及鉴定可用于预防或治疗噪声引起的听力损失的组合物的方法。该方法包括使哺乳动物测试对象暴露于候选组合物和校准的声音或噪声挑战。接下来,在一段时间内在测试对象中监视临时阈值偏移(TTS)。将监测的TTS与暴露于对照组合物的对照受试者的TTS进行比较。是否存在取决于测试对象中监测到的TTS与对照对象的TTS之间的临床相关性和统计学上的显着差异,而统计学上显着的差异则表明候选组合物可用于预防或治疗噪音-诱发听力损失。

著录项

  • 公开/公告号US2018161459A1

    专利类型

  • 公开/公告日2018-06-14

    原文格式PDF

  • 申请/专利权人 SOUND PHARMACEUTICALS INCORPORATED;

    申请/专利号US201515507738

  • 发明设计人 JONATHAN KIL;ERIC D. LYNCH;

    申请日2015-09-02

  • 分类号A61K49;A61B5/12;

  • 国家 US

  • 入库时间 2022-08-21 13:02:57

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