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Mutant chicken interleukin-1β protein as chicken interleukin-1β antagonist and uses thereof
Mutant chicken interleukin-1β protein as chicken interleukin-1β antagonist and uses thereof
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机译:鸡白介素-1β拮抗剂的突变鸡白介素-1β蛋白及其用途
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摘要
The present invention provides a mutant chicken interleukin-1β protein as a chicken interleukin-1β antagonist, which has a substituted peptide at position 117 and/or 118 of wild-type chicken interleukin-1β peptides. The mutant chicken interleukin-1β protein is created by using point mutation in a method genetic engineering; it can significantly inhibit proliferation of avian virus, such as avian influenza virus, avian reovirus and Marek's disease virus, and avian inflammation response. Therefore, the mutant chicken interleukin-1β protein of the present invention can be used as antiviral and anti-inflammatory medication.
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