首页> 外国专利> Mutant chicken interleukin-1β protein as chicken interleukin-1β antagonist and uses thereof

Mutant chicken interleukin-1β protein as chicken interleukin-1β antagonist and uses thereof

机译:鸡白介素-1β拮抗剂的突变鸡白介素-1β蛋白及其用途

摘要

The present invention provides a mutant chicken interleukin-1β protein as a chicken interleukin-1β antagonist, which has a substituted peptide at position 117 and/or 118 of wild-type chicken interleukin-1β peptides. The mutant chicken interleukin-1β protein is created by using point mutation in a method genetic engineering; it can significantly inhibit proliferation of avian virus, such as avian influenza virus, avian reovirus and Marek's disease virus, and avian inflammation response. Therefore, the mutant chicken interleukin-1β protein of the present invention can be used as antiviral and anti-inflammatory medication.
机译:本发明提供了作为鸡白介素-1β拮抗剂的突变鸡白介素-1β蛋白,其在野生型鸡白介素-1β肽的117和/或118位具有取代的肽。突变鸡白细胞介素-1β蛋白是通过基因工程中的点突变产生的。它可以显着抑制禽病毒(如禽流感病毒,禽呼肠孤病毒和马立克氏病病毒)的增殖以及禽类炎症反应。因此,本发明的突变型鸡白介素-1β蛋白可用作抗病毒和抗炎药。

著录项

  • 公开/公告号US10059753B2

    专利类型

  • 公开/公告日2018-08-28

    原文格式PDF

  • 申请/专利权人 NATIONAL TSING HUA UNIVERSITY;

    申请/专利号US201615260017

  • 发明设计人 HSIEN-SHENG YIN;WEN-TING CHEN;

    申请日2016-09-08

  • 分类号C07K14/545;A61K38;

  • 国家 US

  • 入库时间 2022-08-21 13:03:34

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号