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Combined application of isothiocyanate compound and anti-cancer medicine

机译：异硫氰酸酯化合物与抗癌药的联合应用

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摘要

The present invention relates to a combined application of isothiocyanate compounds and anti-cancer drugs, in particular to a composition, comprising: (A) a therapeutically effective amount of a first active ingredient, the first active ingredient being an isothiocyanate compound or derivative thereof; (B) a therapeutically effective amount of a second active ingredient, the second active ingredient being anti-cancer drugs effecting or influencing DNA, kinase inhibitor anti-cancer drugs or endocrine therapy hormonal anti-cancer drugs, the mass ratio of the first active ingredient and the second active ingredient being from 1:10000 to 10000:1. Also disclosed are an active ingredient composition, kit, pharmaceutical composition and uses thereof in the preparation of anti-cancer drugs. The composition, active ingredient composition and kit have excellent effect of inhibiting the growth of cancer cells.

机译：本发明涉及异硫氰酸酯化合物和抗癌药的联合应用，尤其涉及一种组合物，其包含：（A）治疗有效量的第一活性成分，所述第一活性成分是异硫氰酸酯化合物或其衍生物; （B）治疗有效量的第二活性成分，该第二活性成分是影响或影响DNA的抗癌药，激酶抑制剂抗癌药或内分泌治疗激素抗癌药，该第一活性成分的质量比第二种有效成分为1：10000至10000：1。还公开了活性成分组合物，试剂盒，药物组合物及其在制备抗癌药物中的用途。该组合物，活性成分组合物和试剂盒具有优异的抑制癌细胞生长的作用。

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公开/公告号US10010520B2

专利类型
公开/公告日2018-07-03

原文格式PDF
申请/专利权人 JC (WUXI) COMPANY INC.;
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申请/专利号US201414912239
发明设计人 JINGCAI CHENG;CHUNXIA ZHANG;ZHIWEI CHENG;
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申请日2014-08-13
分类号A61K31/16;A61K31/33;A61K31/28;A61K31/58;A61K31/415;A61K38/22;A61K31/26;A61K31/436;A61K31/165;A61K31/44;A61K31/475;A61K31/4985;A61K31/506;A61K31/517;A61K31/69;A61K31/167;A61K31/17;A61K31/282;A61K31/337;A61K31/4164;A61K31/4166;A61K31/4184;A61K31/437;A61K31/4412;A61K31/4439;A61K31/4745;A61K31/519;A61K31/704;A61K31/7068;A61K31/7076;A61K33/24;A61K33/36;A61K38/10;A61K38/14;
国家 US
入库时间 2022-08-21 13:05:08

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