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Local engineering of the lymph node environment to promote immune tolerance

机译:淋巴结环境的局部工程化以提高免疫耐受性

摘要

A method of inducing specific immune tolerance to myelin in an individual is provided. The method includes introducing directly into a lymph node of the individual an effective amount of a composition that contains a myelin antigen, a biodegradable material and at least one tolerogenic agent. The method is suitable for reducing the severity of symptoms of multiple sclerosis in individuals who suffer from primary-progressive multiple sclerosis (PPMS), and can halt or even reverse PPMS progression.
机译:提供了一种诱导个体对髓磷脂的特异性免疫耐受的方法。该方法包括将有效量的包含髓磷脂抗原,可生物降解的材料和至少一种致耐受剂的组合物直接引入个体的淋巴结中。该方法适合于减轻患有原发性进行性多发性硬化症(PPMS)的个体的多发性硬化症症状的严重性,并且可以停止甚至逆转PPMS的进展。

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