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Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation

机译:omega-3甘油酯再灌注促进供体器官移植保护

摘要

It has been discovered that isolated organs and tissues perfused/reperfused in perfusion buffer to which omega-3 glyceride oil had been added retain higher levels of function than if perfused/reperfused without the omega-3 glycerides. Isolated hearts reperfused ex vivo after induced ischemia in n-3 triglyceride perfusion emulsion maintained a normal heart rate and normal LVDP and showed a dramatically reduced frequency of arrhythmias compared to control hearts. Further, test hearts reperfused with n-3 oil triglyceride emulsion showed a decrease in creatine kinase and upregulation of certain beneficial proteins including the anti-apoptotic gene marker Bcl-2.
机译:已经发现,在添加了omega-3甘油酯油的灌注缓冲液中灌注/再灌注的分离的器官和组织比没有omega-3甘油酯的灌注/再灌注的保留了更高水平的功能。与对照组相比,n-3甘油三酸酯灌注乳状液诱导局部缺血后离体心脏再灌注,可维持正常的心律和LVDP,并且心律失常的频率大大降低。此外,用n-3甘油三酸酯乳剂再灌注的测试心脏显示肌酸激酶减少,某些有益蛋白质(包括抗凋亡基因标记Bcl-2)上调。

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