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Process and kit for detecting and monitoring diagnostic biomarkers for post traumatic stress disorder (PTSD) and for distinguishing between suicide and non-suicide forms of the disorder

机译:用于检测和监测创伤后应激障碍(PTSD)的诊断生物标志物以及区分疾病的自杀形式和非自杀形式的方法和试剂盒

摘要

Life-threatening traumas such as terrorist attacks, war, disasters, mental or physical assault, severe accidents and violence frequently provoke emotional and behavioral disturbances known as post-traumatic stress disorder (PTSD) and suicide related thereto. Accurate diagnosis and treatment planning for PTSD and suicide remain difficult. The discovery of specific markers creates new opportunities for more accurate clinical assessments identifying groups that may experience better outcomes when exposed to an intervention. The present invention provides a process of detection of P-11, UBE3A, STY1, EMAP-II, SIP1, ORC5L, DCX, SCYE protein in a biological sample of a subject suspected of suffering from PTSD and/or having suicidal tendencies, and provides additional PTSD markers which are specific to gender.
机译:威胁生命的创伤,例如恐怖袭击,战争,灾难,精神或人身攻击,严重事故和暴力,经常引起称为创伤后应激障碍(PTSD)的情绪和行为障碍,并引起自杀。 PTSD和自杀的准确诊断和治疗计划仍然很困难。特定标志物的发现为更准确的临床评估创造了新的机会,从而可以确定在进行干预时可能会遇到更好结果的人群。本发明提供了在怀疑患有PTSD和/或具有自杀倾向的受试者的生物样品中检测P-11,UBE3A,STY1,EMAP-II,SIP1,ORC5L,DCX,SCYE蛋白的方法,并提供其他针对性别的PTSD标记。

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