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首页> 外国专利> CROSS-SPECIES-SPECIFIC PSCA×CD3, CD19×CD3, C-MET×CD3, ENDOSIALIN×CD3, EpCAM×CD3, IGF-1R×CD3, OR FAPα×CD3 BISPECIFIC SINGLE CHAIN ANTIBODY

CROSS-SPECIES-SPECIFIC PSCA×CD3, CD19×CD3, C-MET×CD3, ENDOSIALIN×CD3, EpCAM×CD3, IGF-1R×CD3, OR FAPα×CD3 BISPECIFIC SINGLE CHAIN ANTIBODY

机译：跨物种专用PSCA×CD3，CD19×CD3，C-MET×CD3，ENDOSIALIN×CD3，EpCAM×CD3，IGF-1R×CD3或FAPα×CD3双特异性单链抗体

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摘要

PROBLEM TO BE SOLVED: To solve the problem in which the species specificity of monoclonal antibodies is a significant impediment in their development as human therapeutic agents, and to provide a cross-species-specific antibodies for CD3.SOLUTION: The present invention relates to a bispecific single chain antibody molecule comprising: a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, where the epitope is part of a specific amino acid sequence; and a second binding domain capable of binding to an antigen selected from among prostate stem cell antigen (PSCA), B-lymphocyte antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), endosialin, the EGF-like domain 1 of EpCAM encoded by exon 2, fibroblast activation protein α (FAPα) and insulin-like growth factor I receptor (IGF-IR or IGF-1R).SELECTED DRAWING: None
机译：解决的问题：解决单克隆抗体的物种特异性是其作为人类治疗剂的发展中的显着障碍的问题，并提供针对CD3的跨物种特异性抗体。双特异性单链抗体分子，其包含：第一结合域，其能够结合人和非黑猩猩灵长类CD3ε链的表位，其中该表位是特定氨基酸序列的一部分;和第二结合结构域，其能够与选自前列腺干细胞抗原（PSCA），B淋巴细胞抗原CD19（CD19），肝细胞生长因子受体（C-MET），内皮唾液酸蛋白，EGF样结构域1的抗原结合由外显子2，成纤维细胞活化蛋白α（FAPα）和胰岛素样生长因子I受体（IGF-IR或IGF-1R）编码的EpCAM。

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