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METHOD FOR PRODUCING CELL FOR SCREENING FOR CONFORMATION DISEASE DRUG AND METHOD FOR SCREENING FOR CONFORMATION DISEASE DRUG
METHOD FOR PRODUCING CELL FOR SCREENING FOR CONFORMATION DISEASE DRUG AND METHOD FOR SCREENING FOR CONFORMATION DISEASE DRUG
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机译:制备用于筛查疾病的药物的方法和筛查疾病的药物的方法
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摘要
PROBLEM TO BE SOLVED: To provide a method for producing a cell for screening for a conformation disease drug and a method for screening for a conformation disease drug.;SOLUTION: According to the present invention, there is provided a method for producing a cell for screening for a conformation disease drug, the method being a method for producing a prion-infected cell for screening for a preventive and/or therapeutic agent for conformation disease. The method comprises a cell culture step of culturing abnormal prion persistently infected cells under the specific conditions in which cell proliferation is suppressed and abnormal type prion protein (PrPsc) is accumulated in the cells so as be saturated therein. According to the present invention, there is also provided a method for screening for a conformational disease drug, the method being a method for screening for a preventive and/or therapeutic agent for conformation disease using prion-infected cells produced by the production method. In the method, test compounds that reduces the amount of aberrant prion protein accumulated in prion-infected cells are selected as candidate compounds.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT
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