MRI METHOD FOR DETERMINING SIGNATURE INDICES OF AN OBSERVED TISSUE FROM SIGNAL PATTERNS OBTAINED BY MOTION-PROBING PULSED GRADIENT MRI

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• 3. MRI method for determining signature indices of an observed tissue from signal patterns obtained by motion-probing pulsed gradient MRI [P] . US10942239B2 . 2021-03-09

  机译： 用于从运动探测脉冲梯度MRI获得的信号模式确定观察组织的签名指数的MRI方法

• 4. MRI METHOD FOR DETERMINING SIGNATURE INDICES OF AN OBSERVED TISSUE FROM SIGNAL PATTERNS OBTAINED BY MOTION-PROBING PULSED GRADIENT MRI [P] . 美国专利： US2018045802A1 . 2018-02-15

  机译： MRI技术从运动脉冲梯度MRI所获得的信号模式中确定观察到的组织的信号指标

• 5. MRI METHOD FOR DETERMINING SIGNATURE INDICES OF AN OBSERVED TISSUE FROM SIGNAL PATTERNS OBTAINED BY MOTION-PROBING PULSED GRADIENT MRI [P] . 世界知识产权组织专利： WO2016166115A1 . 2016-10-20

  机译： MRI技术从运动脉冲梯度MRI所获得的信号模式中确定观察到的组织的信号指标

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• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
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• 4. 大鼠C6胶质瘤SSFP fMRI信号变化幅度与Hoffmann模型分析的DCE MRI血流灌注参数的相关性 [A] . 张峻围 . 2017