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MOLECULE ASSOCIATED WITH ONSET OF GOUT, AND METHOD AND KIT FOR EVALUATING DIATHESIS OF URIC ACID-RELATED DISEASES AND INFLAMMATION-RELATED DISEASES, AND INSPECTION OBJECT AND DRUG
MOLECULE ASSOCIATED WITH ONSET OF GOUT, AND METHOD AND KIT FOR EVALUATING DIATHESIS OF URIC ACID-RELATED DISEASES AND INFLAMMATION-RELATED DISEASES, AND INSPECTION OBJECT AND DRUG
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机译：与痛风发作有关的分子，评估尿酸相关疾病和炎症相关疾病，检查对象和药物的素质的方法和工具包
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摘要
To specify a molecule associated with the onset of gout so as to provide a method for evaluating a diathesis of uric acid-related diseases and a diathesis of inflammation-related diseases, an evaluation kit for carrying out the method, an inspection object, and a drug, on the basis of the molecule specified above, for contributing to the early treatment and prevention of the uric acid-related diseases and inflammation-related diseases. The molecule includes any one protein and cDNA of CNIH2-PACS1, ALDH2, MYL2-CUX2, GCKR, MAP3K11, NPT4, ABCG2, HIST1H2BF/HIST1H4E, HIST1H2BE/HIST1H4D and FAM35A, or proteins of combination thereof with GLUT9, NPT1, URAT1, or NXRN2, and is capable of selectively inducing gout. A molecule includes protein and cDNA of an ABCG2 variant and is capable of selectively and ATP-dependently decreasing urate excretion.
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