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BISPECIFIC OR-GATE CHIMERIC ANTIGEN RECEPTOR RESPONSIVE TO CD19 AND CD20

机译：对CD19和CD20敏感的双特异性或门嵌合抗原受体

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摘要

A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

机译：提供了CD19-OR-CD20嵌合抗原受体（CAR）蛋白构建体。还提供了编码CD19-OR-CD20 CAR的核酸。和使用方法，例如治疗B细胞恶性肿瘤。本发明的CD19-OR-CD20 CAR是双特异性CAR，其在检测到CD19或CD20（或两者）时可触发T细胞活化。它是一种单一分子，可对经过工程设计以稳定表达此CAR的人类T细胞赋予双输入识别功能。

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公开/公告号EP3240805A4

专利类型
公开/公告日2018-05-09

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RESEARCH INSTITUTE;
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申请/专利号EP20150870818
发明设计人 CHEN YVONNE Y.;ZAH EUGENIA;JENSEN MICHAEL C.;
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申请日2015-12-14
分类号C07K16/28;C07K16/46;C07K14/705;C12N15/62;C12N15/85;C12N5/0783;A61K35/17;A61K38;A61K39;C07K14/725;
国家 EP
入库时间 2022-08-21 13:18:20

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