首页> 外国专利> FUSION PROTEIN COMPOSED OF MATRIX METALLOPROTEINASE-2 INHIBITOR PEPTIDE DERIVED FROM AMYLOID-beta PRECURSOR PROTEIN AND TISSUE INHIBITOR OF METALLOPROTEINASE-2

FUSION PROTEIN COMPOSED OF MATRIX METALLOPROTEINASE-2 INHIBITOR PEPTIDE DERIVED FROM AMYLOID-beta PRECURSOR PROTEIN AND TISSUE INHIBITOR OF METALLOPROTEINASE-2

机译：淀粉样β前体蛋白衍生的基质金属蛋白酶2抑制剂肽和金属蛋白酶2组织抑制剂的融合蛋白

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摘要

The present invention provides an agent capable of inhibiting MMP-2 specifically. Disclosed is a fusion molecule composed of a ²-amyloid precursor protein molecule-derived domain having an activity of selectively inhibiting matrix metalloproteinase-2 and a tissue inhibitor of metalloproteinase capable of binding to latent matrix metalloproteinase. Also disclosed are a pharmaceutical composition, a cancer metastasis and/or angiogenesis inhibitor, a therapeutic and/or prophylactic for cardiovascular diseases, and a matrix metalloproteinase-2 inhibitor, each of which comprises the fusion molecule.

机译：本发明提供了能够特异性抑制MMP-2的药剂。公开了一种融合分子，该融合分子由β淀粉样蛋白前体蛋白分子衍生的结构域组成，该结构域具有选择性抑制基质金属蛋白酶-2的活性和能够与潜在基质金属蛋白酶结合的金属蛋白酶组织抑制剂。还公开了药物组合物，癌症转移和/或血管生成抑制剂，心血管疾病的治疗和/或预防剂以及基质金属蛋白酶-2抑制剂，它们各自包含融合分子。

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公开/公告号EP2341138B1

专利类型
公开/公告日2017-11-22

原文格式PDF
申请/专利权人 ORIENTAL YEAST CO. LTD.;
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申请/专利号EP20090819151
发明设计人 HIGASHI SHOUICHI;
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申请日2009-10-05
分类号C12N15/09;A61K38;A61P9;A61P9/04;A61P9/10;A61P35/04;A61P43;C07K14/47;C07K14/81;C07K19;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/99;
国家 EP
入库时间 2022-08-21 13:18:50

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