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Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
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机译:用于制备奈必洛尔的酮中间体的无碱制备方法
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摘要
The invention relates to a process for the preparation of a ketone of a general formula 1 with X being Cl or Br, in particular with X being Cl, with Y being F, Cl, Br, I or H, in particular with Y being F, comprising the steps of: activation of a carboxylic acid by using a peptide coupling agent, coupling of the activated carboxylic acid with a malonic acid derivative providing a ²- ketoester precursor and converting the ² -ketoester precursor to the ketone of the general formula 1.
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