首页> 外国专利> MINIGENE COMPRISING HTPA SIGNAL PEPTIDE, T-CELL EPITOPES, E. COLI LTB AND FURIN SENSITIVE LINKERS

MINIGENE COMPRISING HTPA SIGNAL PEPTIDE, T-CELL EPITOPES, E. COLI LTB AND FURIN SENSITIVE LINKERS

机译:包含HTPA信号肽,T细胞表位,大肠杆菌C.LTB和富林敏感连接剂的Minigene

摘要

The present invention provides minigenes suitable as a prophylactic or therapeutic vaccine against conditions such as cancer, infectious diseases or autoimmune diseases, and pharmaceutical compositions comprising the minigene. The minigenes of the present invention comprise (a) a human tissue plasminogen signal peptide; (b) at least one T-cell epitope; and (c) an E. coli heat labile enterotoxin B subunit; wherein the at least one T-cell epitope is linked to the rest of the minigene, and to any other epitopes, by furin sensitive linkers. In some embodiments of the invention, the minigene comprises T-cell epitopes from one or more of CEA, her-2/neu and hTERT. Also provided herein are immunogenic peptide epitopes of CEA, her-2/neu and hTERT, as well as immunogenic peptide analogs, and pharmaceutical compositions and vaccines comprising one or more of said peptides and analogs for prophylaxis and/or treatment of cancer or other disorder. Methods of inducing an immune response in a patient, in addition to methods of treatment using the minigenes, immunogenic peptides, and peptide analogs disclosed herein are also provided.
机译:本发明提供了适合作为针对诸如癌症,传染病或自身免疫疾病的病症的预防性或治疗性疫苗的小基因,以及包含该小基因的药物组合物。本发明的小基因包含(a)人组织纤溶酶原信号肽; (b)至少一个T细胞表位; (c)大肠杆菌热不稳定肠毒素B亚基;其中所述至少一个T细胞表位通过弗林蛋白酶敏感性接头与所述小基因的其余部分以及与任何其他表位相连。在本发明的一些实施方案中,小基因包含来自CEA,her-2 / neu和hTERT中的一种或多种的T细胞表位。本文还提供了CEA,her-2 / neu和hTERT的免疫原性肽表位,以及免疫原性肽类似物,以及包含一种或多种所述肽和类似物的药物组合物和疫苗,用于预防和/或治疗癌症或其他疾病。 。除了使用本文公开的小基因,免疫原性肽和肽类似物的治疗方法以外,还提供了在患者中诱导免疫应答的方法。

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