首页> 外国专利> METHOD FOR PRODUCING LIPOSOMES BY TWO-STAGE EMULSIFICATION METHOD USING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, METHOD FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE METHOD FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY

METHOD FOR PRODUCING LIPOSOMES BY TWO-STAGE EMULSIFICATION METHOD USING OUTER AQUEOUS PHASE CONTAINING SPECIFIC DISPERSING AGENT, METHOD FOR PRODUCING LIPOSOME DISPERSION OR DRY POWDER THEREOF USING THE METHOD FOR PRODUCING LIPOSOMES, AND LIPOSOME DISPERSION OR DRY POWDER THEREOF PRODUCED THEREBY

机译：使用包含特定分散剂的外部水相通过两阶段乳化法制备脂质体的方法，使用脂质体制备方法制备脂质体分散体或干粉的方法，以及通过脂质体制备方法制备脂质体分散体或干粉体的方法

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摘要

Disclosed is a method for producing liposomes, a liposome dispersion or a dry powder thereof by a two-stage emulsification method using an additive (dispersing agent) whereby a liposome dispersion and a dry powder thereof, which ensure the prevention of the leakage of an encapsulated drug or the like from liposomes during prolonged storage and can be stably used over a long period of time, can be obtained. A method for producing liposomes by a two-stage emulsification method, characterized by using, in the secondary emulsification step, an outer aqueous phase containing a dispersing agent (hereinafter referred to as "a specific dispersing agent") which forms no molecular self-assembly or exclusively forms molecular self-assemblies having a volume-average particle diameter equal to or less than 10 nm; and a method for producing a liposome dispersion and a dry powder thereof using the aforesaid production method. The aforesaid specific dispersing agent preferably contains at least one component selected from among, for example, gelatin, albumin, dextran and a polyalkylene oxide-based compound.

机译：公开了一种通过使用添加剂（分散剂）的两阶段乳化法制备脂质体，脂质体分散体或其干粉的方法，由此脂质体分散体及其干粉确保防止包封物的泄漏。可以在长期保存中从脂质体获得药物等，并且可以长期稳定地使用。一种通过两阶段乳化法生产脂质体的方法，其特征在于，在二次乳化步骤中，使用含有不形成分子自组装的分散剂（以下称为“特定分散剂”）的外部水相。或仅形成体积平均粒径等于或小于10 nm的分子自组装体;或以及使用上述制备方法制备脂质体分散体及其干粉的方法。上述特定分散剂优选包含选自例如明胶，白蛋白，右旋糖酐和基于聚环氧烷的化合物中的至少一种组分。

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公开/公告号EP2450031B1

专利类型
公开/公告日2018-08-29

原文格式PDF
申请/专利权人 KONICA MINOLTA HOLDINGS INC.;
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申请/专利号EP20100793951
发明设计人 MOTOKUI YASUYUKI;WADA TAKESHI;ISODA TAKESHI;
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申请日2010-06-02
分类号A61K9/127;A61K8/14;A61K9/10;A61K9/113;A61K9/14;A61K47/34;A61K47/36;A61K47/42;A61Q19;
国家 EP
入库时间 2022-08-21 13:19:46

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