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首页> 外国专利> Markers for the prediction of a clinical result of a autologous belt disks cell transplantation, to the course / monitoring the course of an autologous belt disks cell transplantation, to assess the quality of the belt disks cells, for the evaluation of the quality of an implant and / or pharmaceutical composition for novel therapies (atmp) for the treatment of a belt disks defect, as well as for the diagnosis of an intervertebral disks - and / or vortex body defect

Markers for the prediction of a clinical result of a autologous belt disks cell transplantation, to the course / monitoring the course of an autologous belt disks cell transplantation, to assess the quality of the belt disks cells, for the evaluation of the quality of an implant and / or pharmaceutical composition for novel therapies (atmp) for the treatment of a belt disks defect, as well as for the diagnosis of an intervertebral disks - and / or vortex body defect

机译：用于预测自体带盘细胞移植的临床结果的标记，用于/自体带盘细胞移植的过程/监控过程，以评估带盘细胞的质量，用于评估植入物的质量和/或用于治疗腰椎间盘突出的新疗法（atmp）的药物组合物，以及用于诊断椎间盘和/或涡旋体缺陷的药物组合物

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摘要

The present invention relates to markers for the use in vitro– in the prediction (prediction) of a clinical result (so-called outcome - prognosis) an autologous belt disks cell transplantation, in particular matrix - associated autologous belt disks cell transplantation,and / or– Course / monitoring the course of an autologous belt disks cell transplantation, in particular matrix - associated autologous belt disks cell transplantation,and / or– in the assessment of the quality of the belt disks cells, preferably for an autologous belt disks cell transplantation, in particular for a matrix - associated autologous belt disks cell transplantation,and / or– in the case of the evaluation of the quality of an implant and / or of a medicament for novel therapies (atmp) for the treatment of a belt disks defect and / or for the reconstruction of intervertebral disk tissueand / or– in the diagnosis of a belt disks defect, in particular of a lumbar, preferably lumbar - sacred, volume disks defect, and / or vortex body defect,the marker is selected from the group consisting of ctx - i, ctx - ii, ntx - i, cpii, vegf, c2c, mmp - 3, hyaluronic acid, tnf - α, il - 1ra, il - 4, comp, ykl - 40, and combinations of at least two of said markers.The present invention also relates to a corresponding an in vitro method, as well as a corresponding kit.
机译：本发明涉及用于体外使用的标记物，用于预测（预测）自体带盘细胞移植的临床结果（所谓的结果-预后），特别是基质相关的自体带盘细胞移植，和/或–对自体带盘细胞移植过程，特别是基质相关自体带盘细胞移植的过程/进行监测，和/或–在评估带盘细胞的质量方面，最好用于自体带盘细胞移植，尤其是与基质相关的自体带盘细胞移植，和/或-在评估用于治疗带盘缺陷的新疗法（atmp）的植入物和/或药物的质量的情况下和/或用于椎间盘组织的重建和/或-在诊断皮带盘缺损，尤其是腰椎，最好是腰椎神圣的容量性椎间盘缺损时和/或涡旋体缺陷，标记物选自ctx-i，ctx-ii，ntx-i，cpii，vegf，c2c，mmp-3，透明质酸，tnf-α，il-1ra， il-4，comp，ykl-40，以及至少两种所述标记物的组合。本发明还涉及相应的体外方法以及相应的试剂盒。

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