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Oxy133 OXYSTEROL ANALOGUE INDUCTS OSTEOGENESIS AND SIGNAL WAY HEDGEHOG AND INHIBITED LIPOGENESIS
Oxy133 OXYSTEROL ANALOGUE INDUCTS OSTEOGENESIS AND SIGNAL WAY HEDGEHOG AND INHIBITED LIPOGENESIS
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机译:Oxy133氧固醇类似物诱导骨生成和信号途径的刺猬和抑制脂肪生成
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FIELD: chemistry.;SUBSTANCE: invention relates to an Oxy133 compound having the formula I ; . ;The invention also relates to a bioactive composition, to methods of treatment and to a method for inducing osteoblastic differentiation and/or inhibiting the differentiation of adipocytes of mesenchymal stem cells of mammals.;EFFECT: new compound has been obtained that is useful for the treatment of bone disease, for increasing osteoporrelation and/or osteoproliferation, to stimulate bone formation, to induce osteoblastic differentiation, or to inhibit the differentiation of adipocytes of mesenchymal stem cells.;8 cl, 15 dwg, 2 tbl, 4 ex
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机译:发明领域本发明涉及具有式I的Oxy133化合物。 。 ;本发明还涉及生物活性组合物,涉及诱导哺乳动物的间充质干细胞的成骨细胞分化和/或抑制其脂肪细胞分化的方法和方法。效果:已经获得了对化合物有用的新化合物。治疗骨病,增加骨质疏松和/或骨增生,刺激骨形成,诱导成骨细胞分化或抑制间充质干细胞的脂肪细胞分化。; 8 cl,15 dwg,2 tbl,4 ex
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