• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> GENETIC (RECOMBINANT) DNA CONSTRUCT COMPRISING CODON-OPTIMIZED GLYCOPROTEIN GENE (PROTEIN G) OF RABIES VIRUS WITH CONSENSUS AMINO ACID SEQUENCE WHICH TAKES INTO ACCOUNT THE AMINO ACID SEQUENCE OF PROTEIN G, ISOLATED FROM RABIES VIRUS STRAIN CIRCULATING IN THE RUSSIAN FEDERATION

GENETIC (RECOMBINANT) DNA CONSTRUCT COMPRISING CODON-OPTIMIZED GLYCOPROTEIN GENE (PROTEIN G) OF RABIES VIRUS WITH CONSENSUS AMINO ACID SEQUENCE WHICH TAKES INTO ACCOUNT THE AMINO ACID SEQUENCE OF PROTEIN G, ISOLATED FROM RABIES VIRUS STRAIN CIRCULATING IN THE RUSSIAN FEDERATION

机译：遗传（重组）DNA结构，由带有病毒的密码子优化的糖蛋白基因（蛋白G）和氨基酸序列组成一致，氨基酸序列考虑到了从病毒株中分离出的糖蛋白G的氨基酸序列。

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

FIELD: biotechnology.;SUBSTANCE: genetic DNA construct represented by the nucleotide sequence SEQ ID NO 2 containing a codon-optimized gene encoding the glycoprotein (G protein) of rabies virus with the consensus amino acid sequence SEQ ID NO 1, taking into account the variety of the rabies virus strains circulating in the territory of the Russian Federation is proposed. The proposed DNA construct in the pVAX1 vector in the transfected human cell culture, provides an increase in protein G gene expression as compared to the expression of the gene of the Vnukovo-32 strain viral protein G in a similar vector.;EFFECT: proposed DNA construct can be used to create an anti-rabies DNA vaccine that provides efficient glycoprotein synthesis in mammalian cells.;2 dwg
机译：技术领域：生物技术;物质：由核苷酸序列SEQ ID NO 2表示的遗传DNA构建体，其中包含密码子优化的编码狂犬病毒糖蛋白（G蛋白）的基因，该基因具有共有氨基酸序列SEQ ID NO 1，并考虑了建议在俄罗斯联邦境内流通的各种狂犬病毒株。与在类似载体中Vnukovo-32株病毒蛋白G的基因表达相比，在转染的人类细胞培养物中的pVAX1载体中拟议的DNA构建提供了蛋白质G基因表达的增加。构建体可用于创建抗狂犬病DNA疫苗，该疫苗可在哺乳动物细胞中提供有效的糖蛋白合成。2dwg

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号