A method for assessing and correcting neurological status based on monitoring parameters of oxidative stress in patients with ischemic stroke

摘要

FIELD: medicine; neurology.SUBSTANCE: invention relates to medicine, namely neurology, and concerns the evaluation and correction of neurological status based on the monitoring of oxidative stress parameters in patients with ischemic stroke. For this, in addition to the standard therapy, alpha-tocopherol acetate and mexidol are administered. Doses and administration regimes are adjusted depending on the severity of the neurological deficit assessed as per the NIHSS scale. In mild cases – eight or less points – alpha-tocopherol acetate – 100–200 mg 1–2 times a day in pellet form, and mexidol – 100 mg in pellet form, with a course of 12 days. At moderately pronounced disorders – from nine to twelve points – alpha-tocopherol acetate – 100–200 mg 1–2 times a day in pellet form, mexidol – 100 mg intramuscularly, with a course of 12 days. With a severe neurologic deficit – more than thirteen points – alpha-tocopherol acetate – in the form of 50 % oil solution intramuscularly, 100 mg per day, mexidol – 600 mg intravenously, by drop infusion, daily for 12 days. Next, the drugs are administered in pellet form: alpha-tocopherol acetate – 200 mg twice a day, mexidol – 50 mg per day, with a course of one month.EFFECT: such a differentiated therapy scheme allows to more accurately adjust the level of indices of oxidative stress, which, in turn, ensures effective restoration of impaired functions, shortening the terms of treatment and rehabilitation in this group of patients.1 cl, 1 tbl, 1 ex

机译：领域：医学;神经学发明领域本发明涉及医学，即神经学，并且涉及基于对缺血性中风患者的氧化应激参数的监测的神经学状态的评估和校正。为此，除标准疗法外，还应使用醋酸α-生育酚和美西多。根据根据NIHSS量表评估的神经功能缺损的严重程度，调整剂量和给药方案。在轻度病例中-八点或以下-醋酸α-生育酚-颗粒形式每天100-200 mg 1-2次，美西多-颗粒形式每天100 mg，疗程为12天。在中等程度的疾病-从9点到12点-醋酸α-生育酚-颗粒形式，每天1–2次100–200 mg，美西多–肌肉内100 mg，疗程12天。患有严重的神经功能缺损-超过13点-乙酸α-生育酚-肌内注射50％油溶液，每天100 mg，美西多-静脉滴注600 mg，每天滴注，持续12天。接下来，药物以小球形式给药：醋酸α-生育酚醋酸盐–每天两次200毫克，甲氧西多–每天50毫克，一个月的疗程。氧化应激指数，依次可确保功能受损的患者有效恢复，从而缩短了该组患者的治疗和康复条件。1cl，1 tbl，1 ex

著录项

公开/公告号RU2016117931A

专利类型
公开/公告日2017-11-10

原文格式PDF
申请/专利权人 ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ ОБРАЗОВАТЕЛЬНОЕ УЧРЕЖДЕНИЕ ВЫСШЕГО ПРОФЕССИОНАЛЬНОГО ОБРАЗОВАНИЯ ВОРОНЕЖСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ИМ. Н.Н. БУРДЕНКО МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (RU);
展开▼

申请/专利号RU20160117931
发明设计人 ЛУЦКИЙ МИХАИЛ АЛЕКСАНДРОВИЧ (RU);ЗЕМСКОВ АНДРЕЙ МИХАЙЛОВИЧ (RU);ЛУШНИКОВА ЮЛИЯ ПАВЛОВНА (RU);СМЕЛЯНЕЦ МАКСИМ АНАТОЛЬЕВИЧ (RU);КАРПОВА ОЛЕСЯ ЮРЬЕВНА (RU);
展开▼

申请日2016-05-06
分类号A61K31;
国家 RU
入库时间 2022-08-21 13:24:00

A method for assessing and correcting neurological status based on monitoring parameters of oxidative stress in patients with ischemic stroke

摘要

著录项

相似文献