首页> 外国专利> THERAPEUTIC AGENT CONTAINING A HUMANIZED ANTIEPIREGULIN ANTIBODY AS AN ACTIVE INGREDIENT FOR NON-SMALL CELL LUNG CARCINOMA, EXCEPT FOR Adenocarcinoma

THERAPEUTIC AGENT CONTAINING A HUMANIZED ANTIEPIREGULIN ANTIBODY AS AN ACTIVE INGREDIENT FOR NON-SMALL CELL LUNG CARCINOMA, EXCEPT FOR Adenocarcinoma

机译:包含人化抗上皮调节蛋白抗体的治疗剂,作为腺癌以外的非小细胞肺癌的有效成分

摘要

The present inventors successfully produced therapeutic agents for non-small cell lung cancer except adenocarcinoma, comprising as active ingredient an anti-Epiregulin antibody that shows cross-species reactivity between the human animal and cynomolgus which is a non-human animal, an anti-Epiregulin antibody with suppressed chemical degradation, an anti-Epiregulin antibody with reduced isoelectric point, an anti-Epiregulin antibody with increased midpoint temperature of thermal denaturation, or an anti-Epiregulin antibody with reduced amount of aggregates, generated by appropriately substituting amino acid residues in the variable-region sequences of a humanized EP27 antibody that inhibits cancer cell proliferation by exerting a cytotoxicity and a neutralizing activity against human Epiregulin-expressing cancer cells.
机译:本发明人成功地制备了用于除腺癌以外的非小细胞肺癌的治疗剂,其包含在人动物与非人动物食蟹猕猴之间表现出种间反应性的抗上皮调节蛋白抗体作为活性成分。化学降解受到抑制的抗体,等电点降低的抗上皮调节蛋白抗体,热变性中点温度升高的抗上皮调节蛋白抗体或聚集体数量减少的抗上皮调节蛋白抗体,通过适当地置换氨基酸残基产生人源化EP27抗体的可变区序列,可通过对表达人上皮调节蛋白的癌细胞发挥细胞毒性和中和作用来抑制癌细胞的增殖。

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