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首页> 外国专利> A method for modeling the process of crystallization of vascular calcifications from an analogue of a human blood plasma solution under conditions close to physiological in vitro

A method for modeling the process of crystallization of vascular calcifications from an analogue of a human blood plasma solution under conditions close to physiological in vitro

机译：一种在接近生理体外条件下模拟人血浆溶液中血管钙化结晶过程的方法

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FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to method for modelling pathological processes of formation of mineral phases in case of pathogenic calcification of collagenous and muscular tissues. Essence of the method lies in obtaining mineral phases, constituting the base of inorganic component of calcificates of human heart valves, in artificial, close to physical medium model system. Model media, close in their inorganic content, pH, ionic power to human blood plasma, with the following composition: solution volume 250 ml, weight of salts (g):CaCl*2HO - 0.1446; KHPO- 0.1288; (NH)HPO- 0.6600*10-3; MgCl*6HO - 0.0482; NaHCO- 0.5460; NaSO- 0.0639; NaCl - 5.7330 g, at pH 7.40±0.05 are created. Observation is carried out for 7 days, the obtained sediment is filtered, dried at t=80±5°C for 5 hours. Carbonatehydroxylapatite with admixture of whitlockite, close in composition to calcificates of human collagenous and muscular tissues is identified in sediment composition.EFFECT: application of the method makes it possible to detect parameters leading to pathogenic calcification of human collagenous and muscular tissues.3 dwg, 5 tbl
机译：技术领域本发明涉及在胶原和肌肉组织的病原性钙化的情况下对矿物质相形成的病理过程建模的方法的模型。该方法的实质在于，在接近物理介质模型系统的人造环境中，获得矿物相，构成人心脏瓣膜钙化的无机成分的基础。模型培养基，其无机含量，pH，对人血浆的离子强度接近，具有以下成分：溶液体积250 ml，盐重量（g）：CaCl * 2HO-0.1446; KHPO- 0.1288; （NH）HPO- 0.6600 * 10-3;氯化镁* 6HO-0.0482;碳酸氢钠-0.5460;硫酸钠-0.0639;产生NaCl-5.7330g，在pH 7.40±0.05下。观察7天，将获得的沉淀物过滤，在t ＝ 80±5℃下干燥5小时。碳酸盐羟基辉石与辉锰矿混合，在沉积物成分中鉴定出与人的胶原和肌肉组织钙化相近的成分。效果：该方法的应用使得检测导致人的胶原和肌肉组织钙化的参数成为可能。3dwg，5 tbl

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