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CNS 2--23--2-OXO-23-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS
CNS 2--23--2-OXO-23-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS
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机译：CNS 2--23--2-OXO-23-二氢吲哚用于治疗CNS疾病
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摘要
The present invention is directed to 2-oxo-2,3-dihydro-indole of the formula (I), or a pharmaceutically acceptable salt, racemic mixture, or a corresponding enantiomer and / or optical isomer and / or stereoisomer thereof It is about: In this formula, (N 1 ) is phenyl or a heteroaryl group selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl and pyrazolyl; (N 2 ) is phenyl or pyridinyl, wherein the N atom of said pyridinyl group may be free at any position; R 1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen; n is 1 or 2; when n is 2, R 1 may be the same or different; R 2 / R 2'is lower alkyl, independently of each other, or C 3-6 together with the carbon atom to which they are attached - form a cycloalkyl ring; R 3 is lower alkyl, C 3-6-cycloalkyl, CH 2 -C 3-6-cycloalkyl, a ring-carbon atoms are replaced by -O- C 3-6-cycloalkyl, (CH 2)3 -OC 3-6-cycloalkyl, hydroxy lower alkyl, lower alkyl substituted by halogen, (CH 2) 3 -S ( O) 2 -C 3 -6 substituted with -cycloalkyl or (CH 2) 2 - S (O) 2 -lower alkyl; R 4 is hydrogen, halogen or lower alkyl; m is 1 or 2; When m is 2, R 4 may be the same or different.
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