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CYP3A7 3'UTR Method to predict the blood concentration of tacrolimus using SNP in 3'UTR of CYP3A7
CYP3A7 3'UTR Method to predict the blood concentration of tacrolimus using SNP in 3'UTR of CYP3A7
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机译：CYP3A7 3'UTR用SNP预测CYP3A7 3'UTR中他克莫司的血药浓度的方法
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摘要
The present invention relates to a method for predicting a drug concentration of an entity with respect to tacrolimus. More specifically, the present invention relates to a composition for predicting a drug concentration of an entity with respect to tacrolimus, wherein the composition includes rs10211 single nucleotide polymorphism (SNP) disposed at CYP3A7; a kit for detecting the SNP; and a method for predicting a drug concentration of an entity with respect to tacrolimus by analyzing a haplotype with respect to the SNP. According to the present invention, a drug concentration of an entity with respect to tacrolimus is predicted in advance according to a genetic difference of entities, so the present invention can be useful in determining a suitable administration amount with respect to tacrolimus. Accordingly, a drug concentration in blood can be made to rapidly reach a suitable treatment region in an early stage, and the occurrence of early rejection and drug side effects is reduced. Thus, the present invention is very useful in ensuring effectiveness and safety of tacrolimus.
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