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Manufacture method for combination of Poly L lactic acid dermal filler and hyaluronic acid dermal filler
Manufacture method for combination of Poly L lactic acid dermal filler and hyaluronic acid dermal filler
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机译：聚乳酸乳酸真皮填充剂与透明质酸真皮填充剂组合的制造方法
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摘要
The present invention provides a method for producing a polylactic acid filler and a hyaluronic acid filler conjugate, which comprises mixing PLLA with CMC and mannitol, freeze-drying, pulverizing the mixture into a predetermined size, and vial- A PLLA preparation step of producing a vial-containing PLLA; A HA preparation step in which HA is mixed with a BDDE cross-linking agent, gelled, washed with a phosphate buffer solution, obtained HA of homogeneous particles, filled in a vial, and autoclaved to produce vial-loaded HA; HA mixed with distilled water, and then injected into a PLLA vial, and mixed and injected into a syringe. Thus, PLLA was lyophilized to prepare a conjugate of PLLA and HA, and HA , Cross-linked HA is injected into PLLA vial, mixed, and then pulled out with a syringe.
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