首页> 外国专利> AZIDE TRACER FOR LABELLING RADIOACTIVE IODINE, PREPARATION METHOD THEREOF, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR RADIOACTIVE IODINE LABELING OR MEDICAL DIAGNOSIS

AZIDE TRACER FOR LABELLING RADIOACTIVE IODINE, PREPARATION METHOD THEREOF, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR RADIOACTIVE IODINE LABELING OR MEDICAL DIAGNOSIS

机译：放射性碘标记的叠氮示踪剂，其制备方法以及与放射性碘标记或医学诊断有效成分相同的成分

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摘要

The present invention relates to an azide compound for labelling radioactive iodine, a preparation method thereof, and a composition containing the same as an active ingredient for radioactive iodine labeling or medical diagnosis. The azide compound for labelling radioactive iodine according to the present invention can label biomolecules or nanoparticles containing dibenzocyclooctyne (DBCO), through a copper-free click reaction with the radioactive iodine at a fast reaction rate and with a high radiochemical yield; is stable in vivo; is rapidly absorbed into the liver and kidney to be accumulated; and exhibits a fast excretion rate to the outside of a body, thereby being usefully used for radioactive iodine labeling or medical diagnosis of the biomolecules or the nanoparticles.;COPYRIGHT KIPO 2017

机译：本发明涉及用于标记放射性碘的叠氮化物，其制备方法以及包含该化合物作为用于放射性碘标记或医学诊断的活性成分的组合物。根据本发明的用于标记放射性碘的叠氮化物可以通过与铜的无碘咔嗒反应以快速的反应速率和高的放射化学产率标记含有二苯并环辛炔（DBCO）的生物分子或纳米颗粒。在体内稳定;被肝脏和肾脏迅速吸收并积累;并显示出快速排泄到体外，因此可用于放射性碘标记或生物分子或纳米颗粒的医学诊断。; COPYRIGHT KIPO 2017

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公开/公告号KR20170031305A

专利类型
公开/公告日2017-03-21

原文格式PDF
申请/专利权人 KOREA ATOMIC ENERGY RESEARCH INSTITUTE;
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申请/专利号KR20150128508
发明设计人 JEON JONG HOKR;KANG JUNG AEKR;SIM HA EUNKR;NAM YOU REEKR;LEE DONG EUNKR;CHOI DAE SEONGKR;PARK SANG HYUNKR;JANG BEOM SUKR;
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申请日2015-09-10
分类号G01N33/60;A61K49/04;C07C233/64;C07D487/04;
国家 KR
入库时间 2022-08-21 13:27:54

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