The present invention relates to nucleic acid molecules that inhibit the expression of Daxx by RNA interference. The present invention also provides a recombinant expression vector comprising a nucleic acid molecule that inhibits expression of Daxx, a nucleotide sequence encoding TRAIL, and a nucleic acid molecule that inhibits the expression of Bcl-xL, an antitumor composition comprising the same, To the introduced adenovirus. According to the present invention, it is possible to inhibit the expression of Daxx by Daxx shRNA, thereby increasing not only the apoptosis effect but also the replication ratio of adenovirus. By inhibiting the expression of Bcl-xL by Bcl-xL shRNA, Thereby increasing the apoptosis effect and maximizing the antitumor effect.
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