首页> 外国专利> Daxx TRAIL Bcl-xL An expression vector comprising nucleic acid downregulating Daxx TRAIL gene and nucleic acid downregulating Bcl-xL

Daxx TRAIL Bcl-xL An expression vector comprising nucleic acid downregulating Daxx TRAIL gene and nucleic acid downregulating Bcl-xL

机译:Daxx TRAIL Bcl-xL一种表达载体,包含下调Daxx TRAIL基因的核酸和下调Bcl-xL的核酸

摘要

The present invention relates to nucleic acid molecules that inhibit the expression of Daxx by RNA interference. The present invention also provides a recombinant expression vector comprising a nucleic acid molecule that inhibits expression of Daxx, a nucleotide sequence encoding TRAIL, and a nucleic acid molecule that inhibits the expression of Bcl-xL, an antitumor composition comprising the same, To the introduced adenovirus. According to the present invention, it is possible to inhibit the expression of Daxx by Daxx shRNA, thereby increasing not only the apoptosis effect but also the replication ratio of adenovirus. By inhibiting the expression of Bcl-xL by Bcl-xL shRNA, Thereby increasing the apoptosis effect and maximizing the antitumor effect.
机译:本发明涉及通过RNA干扰抑制Daxx表达的核酸分子。本发明还提供了重组表达载体,其包含抑制Daxx表达的核酸分子,编码TRAIL的核苷酸序列和抑制Bcl-xL表达的核酸分子,包括其的抗肿瘤组合物。腺病毒。根据本发明,有可能通过Daxx shRNA抑制Daxx的表达,从而不仅增加细胞凋亡作用,而且增加腺病毒的复制率。通过Bcl-xL shRNA抑制Bcl-xL的表达,从而提高细胞凋亡作用并最大化抗肿瘤作用。

著录项

  • 公开/公告号KR101683964B1

    专利类型

  • 公开/公告日2016-12-09

    原文格式PDF

  • 申请/专利权人 연세대학교 산학협력단;

    申请/专利号KR20140065431

  • 发明设计人 송재진;김주항;강수진;

    申请日2014-05-29

  • 分类号C12N15/11;A61K31/711;A61P35;C12N15/63;

  • 国家 KR

  • 入库时间 2022-08-21 13:28:34

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号