The present invention relates to a novel 6-amino-5- (substituted) pyrimidine-2,4 (1H, 3H) -dione derivative or a pharmaceutically acceptable salt thereof, a process for preparing the same, A pharmaceutical composition for preventing or treating osteogenic differentiation, and a composition for inducing bone differentiation of stem cells. Since the pharmaceutical composition comprising the 6-amino-5-substituted pyrimidine-2,4 (1H, 3H) -dione derivative according to the present invention promotes osteoblast differentiation and mineralization to promote osteogenesis, And can be usefully used as a prophylactic and therapeutic agent for bone diseases including osteoporosis. In addition, since the BMP-2 pathway can be activated, bone differentiation of the stem cells induced thereby can be promoted.
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