首页> 外国专利> VACCINE DIRECTED TO INDUCTION OF IMMUNE RESPONSE TO PROTEIN AND GLYCOLIPID ANTIGENS OF BACTERIAL CELLS THROUGH INTERACTION OF CD40L/CD40 RECEPTOR AXIS WITH COMPLEX OF GLYCOLIPID/CD1D RECEPTOR IN NKT CELLS AND IN DENDRITIC CELLS

VACCINE DIRECTED TO INDUCTION OF IMMUNE RESPONSE TO PROTEIN AND GLYCOLIPID ANTIGENS OF BACTERIAL CELLS THROUGH INTERACTION OF CD40L/CD40 RECEPTOR AXIS WITH COMPLEX OF GLYCOLIPID/CD1D RECEPTOR IN NKT CELLS AND IN DENDRITIC CELLS

机译：通过CD40L / CD40受体轴与糖脂/ CD1D受体复合物在NKT细胞和树突状细胞中的相互作用，诱导疫苗诱导对细菌细胞的蛋白质和糖脂抗原的免疫反应

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摘要

A combination of components to promote an innate and adaptive immune response comprising of a TAA/ecdCD40L vaccine and a complex between the CD1d receptor and an alpha galactosyl ceramide like glycolipid (AGCLGL), to activate NKT cells and activate the CD40 receptor on the DCs and increase the level of the adaptive immune response induced by the TAA/ecdCD40L vaccine to the TAA. The result and advantage of using both the TAA/ecdCD40L vaccine and the ?-galactosylceramide-CD1d complex (or a related bacterial or other antigen related to ?-galactosylceramide) to stimulate the immune response through the CD40L/CD40 axis on dendritic cells, is that the magnitude of the stimulation is robust and increased significantly more than additive- i.e. synergistically due to the interaction, cross-talk and/or cross-stimulation of the glycolipid-CD1d pathway and TAA/ecdCD40L pathway. As a result, a potent immune response is induced against lipid target antigens as well as protein target antigens.

机译：促进先天性和适应性免疫应答的成分的组合，包括TAA / ecdCD40L疫苗以及CD1d受体与α半乳糖神经酰胺（如糖脂）（AGCLGL）之间的复合物，以激活NKT细胞并激活DC和DC上的CD40受体。增加由TAA / ecdCD40L疫苗诱导的针对TAA的适应性免疫应答的水平。同时使用TAA / ecdCD40L疫苗和β-半乳糖苷神经酰胺-CD1d复合物（或与β-半乳糖苷神经酰胺有关的细菌或其他抗原）刺激树突状细胞通过CD40L / CD40轴的免疫反应的结果和优势是由于糖脂-CD1d途径和TAA / ecdCD40L途径的相互作用，串扰和/或交叉刺激，刺激的程度很强，并且比加性要大得多。结果，针对脂质靶标抗原以及蛋白质靶标抗原诱导了有效的免疫应答。

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公开/公告号WO2017189722A1

专利类型
公开/公告日2017-11-02

原文格式PDF
申请/专利权人 MICROVAX LLC;
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申请/专利号WO2017US29631
发明设计人 DEISSEROTH ALBERT B.;
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申请日2017-04-26
分类号A61K39/02;A61K31/70;A61K38/16;A61P37;
国家 WO
入库时间 2022-08-21 13:29:07

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