首页> 外国专利> SENSOR FOR CORTISOL ANALYSIS, METHOD FOR CORTISOL ANALYSIS, REAGENT FOR STRESS EVALUATION, METHOD FOR STRESS EVALUATION, TEST REAGENT FOR CORTISOL-RELATED DISEASE, AND TEST METHOD FOR CONTRACTION RISK OF CORTISOL-RELATED DISEASE

SENSOR FOR CORTISOL ANALYSIS, METHOD FOR CORTISOL ANALYSIS, REAGENT FOR STRESS EVALUATION, METHOD FOR STRESS EVALUATION, TEST REAGENT FOR CORTISOL-RELATED DISEASE, AND TEST METHOD FOR CONTRACTION RISK OF CORTISOL-RELATED DISEASE

机译:用于皮质醇分析的传感器,用于皮质醇分析的方法,用于应力评估的试剂,用于应力评估的方法,用于与皮质醇有关的疾病的测试试剂以及用于与皮质醇有关的疾病的控制风险的测试方法

摘要

Provided are: a novel sensor for cortisol analysis that is usable for analyzing cortisol; a method for cortisol analysis; a reagent for stress evaluation; a method for stress evaluation; a test reagent for a cortisol-related disease; and a test method for the contraction risk of a cortisol-related disease.The sensor for cortisol analysis according to the present invention, said sensor comprising at least one nucleic acid molecule selected from the group consisting of (I), (II) and (III) each containing a binding region (A) that binds to a target and a G-formation region (D) that forms a G-quartet structure, is characterized in that: the target is cortisol; in the absence of the target, the formation of a G-quartet structure is inhibited and thus the G-formation region (D) becomes inactive; and in the presence of the target, the G-formation region (D) forms a G-quartet structure and becomes active.
机译:提供:一种新颖的用于皮质醇分析的传感器,可用于分析皮质醇;皮质醇分析的方法;压力评估试剂;压力评估的方法;皮质醇相关疾病的测试试剂;以及与皮质醇相关疾病的收缩风险的测试方法。根据本发明的用于皮质醇分析的传感器,所述传感器包含至少一种选自(I),(II)和(III)的核酸分子,所述核酸分子各自包含与靶标结合的结合区(A)。其特征在于,目标是皮质醇;目标是皮质醇;形成G四方结构的G形成区域(D)。在没有靶的情况下,抑制了G四方结构的形成,因此G形成区域(D)变得无效。并且,在有靶的情况下,G形成区域(D)形成G四重奏结构并成为活性。

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