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METHOD FOR SIMULTANEOUSLY COMPLETING GENE LOCUS, CHROMOSOME AND LINKAGE ANALYSIS
METHOD FOR SIMULTANEOUSLY COMPLETING GENE LOCUS, CHROMOSOME AND LINKAGE ANALYSIS
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机译：同时完成基因座，染色体和连锁分析的方法
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摘要
A method for simultaneously completing gene locus, chromosome and linkage analysis. The method comprises the following steps: acquire an embryonic cell sample, whole genome amplification, target gene mutation locus amplification, library building of a whole genome amplification product and a target gene mutation locus, high-throughput sequencing, and data analysis; and by utilizing a whole genome amplification technology and combining the high-throughput sequencing, a plurality of comprehensive detection items is completed in one step. The method provides a favorable condition for a trace sample, not only can be used for PGD detection to determine whether embryos carry virulence genes or not and an abnormal chromosome copy number situation, but also is suitable for genetic screening of the embryos of older women suffering from recurrent abortion, one-step completion of multiple detection of a single sample is realized, the operation is simple, the period is short, and the feasibility is strong.
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