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首页> 外国专利> RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS)

RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS)

机译：预防和治疗发炎性肠病（IBD）和肠易激综合征（IBS）的重组菌

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摘要

The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction of the trappin-2 protein, a member of the WAP family proteins or an active fraction of a member of the WAP family proteins or a member of the Serpin family proteins or an active fraction of a member of the Serpin family proteins for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction of the trappin-2 protein, a gene coding for a member of the WAP family proteins or an active fraction of a member of the WAP family proteins, or a gene coding for a member of the serpin family proteins or an active fraction of a member of the serpin family proteins.
机译：本发明涉及炎性肠病（IBD）和/或肠易激综合症（IBS）的一般治疗领域。因此，本发明涉及选自trappin-2蛋白或trappin-2蛋白的活性部分，WAP家族蛋白的成员或WAP家族蛋白的成员的活性部分或分子的分子。 Serpin家族蛋白或Serpin家族蛋白成员的活性级分，用于治疗肠易激综合症（IBS）。本发明还涉及一种重组食品级细菌，其包含选自编码trappin-2蛋白或trappin-2蛋白活性部分的基因，编码WAP家族蛋白成员或活性蛋白的基因的基因。 WAP家族蛋白成员的一部分，或编码丝氨酸蛋白酶抑制剂家族蛋白成员的基因或丝氨酸蛋白酶抑制剂家族蛋白成员的活性组分的基因。

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