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HISTONE DEACETYLASE AND TUBULIN DEACETYLASE INHIBITORS
HISTONE DEACETYLASE AND TUBULIN DEACETYLASE INHIBITORS
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机译：组蛋白去乙酰化酶和微管蛋白去乙酰化酶抑制剂
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摘要
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes ~ "isorubacin" class and "isoisotubacin" class- ~ all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
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