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ANALOGS OF SHK TOXIN AND THEIR USES IN SELECTIVE INHIBITION OF KV1.3 POTASSIUM CHANNELS
ANALOGS OF SHK TOXIN AND THEIR USES IN SELECTIVE INHIBITION OF KV1.3 POTASSIUM CHANNELS
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机译：SHK毒素的类似物及其在KV1.3钾离子通道选择性抑制中的应用。
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摘要
Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogsgenerally comprise ShK toxin attached to a chemical entity (e.g. an atom,molecule, group, residue, compound, moiety, etc.) that has an anionic charge.In some embodiments the chemical entity attached to the ShK toxin may comprisean amino acid residue. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or tootherwise treat diseases or disorders. In some embodiments, the chemicalentity to which the ShK toxin is attached may be chosen to provide selectiveinhibition of certain potassium channels (e.g., Kv1.3 channels) over otherpotassium channels (e.g., Kv1.1 channels). In come embodiments, the chemicalentity to which the ShK toxin is attached may include a fluorophore, therebyproviding a fluorophore tagged ShK analog. Such fluorophore tagged ShK analogsmay be used in flow cytometry alone, or in conjunction with class II tetramersthat can detect autoreactive cells.
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