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Derivative of 4,5-diaryl-3,4-dihydropyrimidine-2(1H)-thione, and a method for preparing a derivative of 4,5-diaryl-3,4-dihydropyrimidine-2(1H)-thione
Derivative of 4,5-diaryl-3,4-dihydropyrimidine-2(1H)-thione, and a method for preparing a derivative of 4,5-diaryl-3,4-dihydropyrimidine-2(1H)-thione
the subject invention is a phenolic derivative of 4,5 - diarylo - 3,4 - dihydropirymidyno - 2 (1h) - tionu, namely, 4 - (3 - hydroksyarylo) - 5 - arylo - 3,4 - dihydropirymidyno - 2 (1h) - mutation model and where the substituent y1, y2, y3,y4 means hydrogen atom or chlorine or fluorine or hydroxyl group, or a group alkilowu0105 c1 - c6 or alkoksylowu0105 c1 - c6 or aryloksylowu0105 or group alkenylowu0105 c1 - c6 or arylowa connected by one carbon atom or group arylowu0105 combined by two carbon atoms, comprising atoms zwiu0105zan e of y2 and y3 or y3 and y4 and substituent ar is formula iii, where x is carbon or nitrogen atom, z1, z2,z3 means hydrogen or fluorine atom atom or chlorine atom or group alkilowu0105 c1 - c6 or alkoksylowu0105 c1 - c6 or aryloksylowu0105 or group acyloksylowu0105 or c1 - c6 or arylowu0105 alkenylowu0105 group connected by one carbon atom or group arylowu0105 combined by two carbon atoms, including ato we associated with z1 and z2 z2 and z3 or a substituent r in the model and,hydrogen atom or group means alkilowu0105 c1 - c6 or ch2ar or ar, ar is formula iii where the substituent.the invention concerns the manufacture of 4,5 - also diarylo - 3,4 - dihydropiryrmdyno - 2 (1h) - tionu, which consists in combining tetrabutyloamoniowego fluoride (bu4nf) solution in the organic solvent containing 5 - arylo - 4 - (3 - alkilosililoksyarylo) - 3,4 - dihydropirymidyno - 2 (1h) - mutation of bs ploughing ii.the reaction results in water free conditions in an inert gas atmosphere at room temperature, after which the mixture are acidified, mixed at room temperature, then the mixture is extracted with solvent niemieszaju0105cym with water, and is washed with aqueous organic extracts solution the weak rules, separates the organic layer.and the water is removed by the addition of binding water, drained which oddestylowuje solvent, and the residue is purified by column chromatography. is 4 - (3 - hydroksyarylo) - 5 - arylo - 3,4 - dihydropirymidyno 2 (1h) - mutation model and which exhibits antiproliferative activity in relation to the action of tumour cells of human cancer.
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