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A NOVEL PROCESS OF FRAGMENTATION OF BACTERIAL POLYSACCHARIDES AND PREPARATION OF CONJUGATE VACCINES THEREOF
A NOVEL PROCESS OF FRAGMENTATION OF BACTERIAL POLYSACCHARIDES AND PREPARATION OF CONJUGATE VACCINES THEREOF
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机译：细菌多糖裂解的新工艺及其共轭疫苗的制备
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摘要
The present invention provides a simple,reproducible, inexpensive and convenient method for facile cleavage of high molecular weight bacterial cell surface native Polysaccharides by invacuo heating thus obtaining antigenic Polysaccharide fragments with size reduced by a factor not more than 10 times. The said depolymerized polysaccharides can be used for synthesis of Polysaccharide-protein conjugate vaccines.
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