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ECO-FRIENDLY METHODOLOGY FOR THE SYNTHESIS OF 2,2-DIMETHYL PROPANOATE COMPOUNDS CATALYZED BY LIPASE IN SUPERCRITICAL CARBON DIOXIDE AS A GREENER REACTION SYSTEM.
ECO-FRIENDLY METHODOLOGY FOR THE SYNTHESIS OF 2,2-DIMETHYL PROPANOATE COMPOUNDS CATALYZED BY LIPASE IN SUPERCRITICAL CARBON DIOXIDE AS A GREENER REACTION SYSTEM.
The present invention offers an efficient green protocol for the synthesis of novel 2,2-dimethyl propanoate esters in the SCCO2 as a reaction media. This method has numerous advantages like use of the green biocatalyst and reaction media which fulfilled a complete green chemistry aspect. Moreover, the present invention reports an efficient method for the synthesis of various types of alkyl 2,2- dimethyl propanoate esters with broad substrate array like (alkyl, cycloalkyl, aryl, phenyl and heterocyclic alkyl). The reaction method used is very simple, recyclable and suitable for scale-up applications which involve the simple down-streaming process to get preferred product. This protocol offers 40-99 % yield of the corresponding alkyl 2,2-dimethyl propanoate compounds. FIGURE: Nil 1PQ HUHBAI 21-12-2 O 1 t
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机译：本发明提供了一种有效的绿色方案，用于在作为反应介质的SCCO 2中合成新型2，2-二甲基丙酸酯。该方法具有许多优点，例如使用绿色生物催化剂和反应介质，可以满足完整的绿色化学要求。而且，本发明报道了一种有效的方法，用于合成具有宽底物阵列（烷基，环烷基，芳基，苯基和杂环烷基）的各种类型的2，2-二甲基丙酸烷基酯。所使用的反应方法非常简单，可回收利用，适用于规模扩大的应用，其中涉及简单的下游工艺以获得首选产品。该方案提供了相应的2，2-二甲基丙酸烷基酯化合物40-99％的产率。图：无1PQ HUHBAI 21-12-2 O 1吨
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