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In vitro methods for identifying/selecting antibodies that are more active in a tumor microenvironment than a non-tumor microenvironment
In vitro methods for identifying/selecting antibodies that are more active in a tumor microenvironment than a non-tumor microenvironment
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机译：鉴定/选择在肿瘤微环境中比非肿瘤微环境更具活性的抗体的体外方法
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摘要
Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.
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