首页> 外国专利> compound, pharmaceutical composition, method of treatment, method of treating a disease or condition caused, exacerbated or resulting from an excess of platelets or unwanted activation of platelets in a patient, method for reducing a patient's circulating platelet count and use

compound, pharmaceutical composition, method of treatment, method of treating a disease or condition caused, exacerbated or resulting from an excess of platelets or unwanted activation of platelets in a patient, method for reducing a patient's circulating platelet count and use

机译：化合物，药物组合物，治疗方法，治疗因患者体内血小板过多或血小板不必要活化而引起，加重或导致的疾病或病症的方法，减少患者循环血小板计数的方法和用途

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摘要

In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

机译：一方面，本发明提供了式I的化合物，其中在式I中，变量X1，X2a，X2b，X2c，R1，B，L，E，A和下标n如本文所定义。在另一方面，本发明提供了包含式I化合物的药物组合物，以及使用式I化合物治疗以表达或过表达为特征的疾病和病症（例如，癌症，血小板增多症等）的方法Bcl-2抗凋亡蛋白的表达，例如抗凋亡Bcl-xL蛋白的表达。

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公开/公告号BRPI0918337A2

专利类型
公开/公告日2017-05-30

原文格式PDF
申请/专利权人 ABBOTT LABORATORIES;GENENTECH INC;THE WALTER AN ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;
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申请/专利号BR2009PI18337
发明设计人 ANDREW J. SOUÉRS;ANDREW M. PETROS;BRAD EDMUND SLEEBS;BRIAN JONH SMITH;CARL STEVEN RYE;CHINH THIEN BUI;CHUDI NDUBAKU;DANETTE A. DUDLEY;GEORGE NIKOLAKOPOULOS;GUILLAUME LAURENT LESSENE;JONATHAN BAYLDON BAELL;JONH A. FLYGARE;KEITH GEOFFREY WATSON;PETER COLMAN;PETER CZABOTAR;STEVEN W. ELMORE;WAYNE J. FAIRBROTHER;
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申请日2009-12-17
分类号A61K31/535;
国家 BR
入库时间 2022-08-21 13:39:42

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