首页> 外国专利> compound, stable antibody-producing cell line, composition, methods for modulating an immune response in an individual and for treating and / or preventing disease, uses of a compound and / or composition and dendritic cells or precursors thereof, methods to enrich and detect dendritic cells or a subset or precursors thereof, polypeptide, vector polynucleotide, host cell, transgenic plant, transgenic non-human animal, extract, process for preparing a compound or polypeptide, enriched dendritic cell population and / or precursors expanded dendritic cell population and / or precursors thereof, methods for identifying a molecule that binds to a polypeptide and screening for a compound that binds to a polypeptide, use of a polypeptide, a polynucleotide, a vector , a host cell, a transgenic plant, an extract, a cell population and / or a composition. tion, method for producing a compound, and kit.

compound, stable antibody-producing cell line, composition, methods for modulating an immune response in an individual and for treating and / or preventing disease, uses of a compound and / or composition and dendritic cells or precursors thereof, methods to enrich and detect dendritic cells or a subset or precursors thereof, polypeptide, vector polynucleotide, host cell, transgenic plant, transgenic non-human animal, extract, process for preparing a compound or polypeptide, enriched dendritic cell population and / or precursors expanded dendritic cell population and / or precursors thereof, methods for identifying a molecule that binds to a polypeptide and screening for a compound that binds to a polypeptide, use of a polypeptide, a polynucleotide, a vector , a host cell, a transgenic plant, an extract, a cell population and / or a composition. tion, method for producing a compound, and kit.

机译:化合物,稳定的抗体产生细胞系,组合物,调节个体免疫应答和治疗和/或预防疾病的方法,化合物和/或组合物和树突状细胞或其前体的用途,富集和检测树突状细胞的方法细胞或其子集或前体,多肽,载体多核苷酸,宿主细胞,转基因植物,转基因非人类动物,提取物,化合物或多肽的制备方法,富集的树突状细胞群和/或前体扩增的树突状细胞群和/或其前体,鉴定与多肽结合的分子并筛选与多肽结合的化合物的方法,多肽,多核苷酸,载体,宿主细胞,转基因植物,提取物,细胞群的用途和/或构图。 ,化合物的生产方法和试剂盒。

摘要

The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen presenting dendritic cells. In particular, the present invention relates to compounds such as antibodies that bind these proteins. These compounds can be used to detect and/or enrich a subset of dendritic cells or precursors thereof. These compounds can also be used to target antigens to dendritic cells or precursors thereof to modulate a humoral and/or T cell mediated immune response to an antigen, or used to target cytotoxic agents to dendritic cells or precursors thereof involved in diseased states.
机译:本发明涉及鉴定位于树突细胞或其前体,特别是呈递抗原的树突细胞的细胞表面上的蛋白质。特别地,本发明涉及结合这些蛋白质的化合物,例如抗体。这些化合物可用于检测和/或富集树突状细胞或其前体的子集。这些化合物还可用于将抗原靶向树突细胞或其前体以调节对抗原的体液和/或T细胞介导的免疫反应,或用于将细胞毒性剂靶向涉及疾病状态的树突细胞或其前体。

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