首页> 外国专利> rodent, pd-1 polypeptide, isolated cell or rodent tissue, rodent embryonic stem cell, methods of producing a rodent, reducing tumor growth in a rodent, killing tumor cells in a rodent, and evaluating pharmacokinetic properties of a drug that targets human pd-1, and, rodent tumor model?

rodent, pd-1 polypeptide, isolated cell or rodent tissue, rodent embryonic stem cell, methods of producing a rodent, reducing tumor growth in a rodent, killing tumor cells in a rodent, and evaluating pharmacokinetic properties of a drug that targets human pd-1, and, rodent tumor model?

机译：啮齿动物，pd-1多肽，分离的细胞或啮齿动物组织，啮齿动物胚胎干细胞，产生啮齿动物，减少啮齿动物中肿瘤生长，杀死啮齿动物中肿瘤细胞以及评估靶向人pd-的药物的药代动力学特性的方法1，还有，啮齿动物的肿瘤模型？

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摘要

non-human animals and methods and compositions for producing and using them are provided, wherein said non-human animals comprise a humanization of a programmed cell death gene 1 (pdcd1). such nonhuman animals may be described, in some embodiments, as having a genetic modification to an endogenous pdcd1 gene, such said nonhuman animals expressing a pd-1 polypeptide that includes a human portion and an endogenous portion (e.g., a nonhuman portion).

机译：本发明提供了非人类动物以及产生和使用它们的方法和组合物，其中所述非人类动物包括程序化细胞死亡基因1（pdcd1）的人源化。在一些实施方案中，此类非人类动物可被描述为对内源性pdcd1基因具有遗传修饰，所述非人类动物表达包含人部分和内源性部分（例如非人部分）的pd-1多肽。

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公开/公告号BR112016029650A2

专利类型
公开/公告日2017-10-24

原文格式PDF
申请/专利权人 REGENERON PHARMACEUTICALS INC.;
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申请/专利号BR20161129650
发明设计人 ALEXANDER O. MUJICA;ANDREW J. MURPHY;ELENA BUROVA;KA-MAN VENUS LAI;
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申请日2015-06-19
分类号C07K16/28;A01K67/027;C07K14/705;C12N15/85;
国家 BR
入库时间 2022-08-21 13:39:51

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