首页>
外国专利>
biocompatible gel comprising nanoparticles and / or nanoparticle aggregates; and kit comprising a biocompatible gel
biocompatible gel comprising nanoparticles and / or nanoparticle aggregates; and kit comprising a biocompatible gel
展开▼
机译：包含纳米颗粒和/或纳米颗粒聚集体的生物相容性凝胶;和包括生物相容性凝胶的试剂盒
展开▼
页面导航
摘要
著录项
相似文献
摘要
biocompatible gel comprising nanoparticles and / or nanoparticle aggregates; and kit comprising a biocompatible gel the present invention relates to compositions and methods for use in the diagnosis and medical monitoring of the patient, typically in the context of therapy, particularly in the context of oncology to optimize local irradiation of the tumor bed. and more particularly relates to a biocompatible gel comprising nanoparticles and / or nanoparticle aggregates, wherein i) the density of each nanoparticle and each nanoparticle aggregate is at least 7 g / cm3, the nanoparticle or nanoparticle aggregate comprising a inorganic material comprising at least one metal element having an atomic number z of at least 25, more preferably at least 40, each of said nanoparticles and each of said nanoparticle aggregates being covered with a biocompatible coating; (ii) the concentration of nanoparticles and / or nanoparticle aggregates is at least about 1% (w / w); and iii) the apparent viscosity at 2 s -1 of the gel comprising nanoparticles and / or nanoparticle aggregates is between about 0.1 ppm and about 1000 ppm when measured between 20 ° C and 37 ° C. 1/1
展开▼
机译：包含纳米颗粒和/或纳米颗粒聚集体的生物相容性凝胶;包含生物相容性凝胶的试剂盒和试剂盒本发明涉及用于患者的诊断和医学监测的组合物和方法，通常在治疗的范围内，特别是在肿瘤学的范围内以优化肿瘤床的局部照射。更具体地，涉及一种包含纳米颗粒和/或纳米颗粒聚集体的生物相容性凝胶，其中i）每个纳米颗粒和每个纳米颗粒聚集体的密度为至少7g / cm 3，该纳米颗粒或纳米颗粒聚集体包括包含至少一种金属的无机材料。原子序数z至少为25，更优选至少为40的元素，每个所述纳米颗粒和每个所述纳米颗粒聚集体均覆盖有生物相容性涂层; （ii）纳米颗粒和/或纳米颗粒聚集体的浓度为至少约1％（w / w）;和iii）当在20℃至37℃之间测量时，包含纳米颗粒和/或纳米颗粒聚集体的凝胶在2s -1的表观粘度为约0.1ppm至约1000ppm。
展开▼
