首页> 外国专利> multicomponent crystalline particles for inhalation therapy, pharmaceutical composition, dry powder inhaler, pressurized metered dose inhaler, methods of treating a respiratory disease or disorder or a lung disease or disorder in a patient, and of preparing the particles

multicomponent crystalline particles for inhalation therapy, pharmaceutical composition, dry powder inhaler, pressurized metered dose inhaler, methods of treating a respiratory disease or disorder or a lung disease or disorder in a patient, and of preparing the particles

机译:用于吸入疗法的多组分晶体颗粒,药物组合物,干粉吸入器,加压定量吸入器,治疗患者的呼吸系统疾病或病症或肺部疾病或病症的方法以及制备该颗粒的方法

摘要

Pharmaceutical Preparations Multi-component crystalline particles and compositions, methods for their preparation, their uses in inhalation therapy and inhaler devices containing said particles are provided, in particular particles comprising glycopyrrolate. The particles can be prepared substantially free of excipients and agents other than active agents or their precursors in the presence of ultrasonic irradiation in a process comprising contacting a solution in a first flowing stream with an anti-solvent in a re-circulating second flowing stream, causing the mixing thereof and collecting crystals that are generated.
机译:药物制剂提供了多组分晶体颗粒和组合物,其制备方法,其在吸入疗法中的用途以及包含所述颗粒的吸入器装置,特别是包含格隆溴铵的颗粒。可以在以下过程中在超声辐射的存在下制备基本上不含赋形剂和活性剂或其前体以外的赋形剂的颗粒,该过程包括使第一流动物流中的溶液与反溶剂在再循环的第二流动物流中接触,导致其混合并收集生成的晶体。

著录项

  • 公开/公告号BR112015018120A2

    专利类型

  • 公开/公告日2017-07-18

    原文格式PDF

  • 申请/专利权人 PROSONIX LIMITED;

    申请/专利号BR20151118120

  • 发明设计人 BURNS JOHN;KARKI SHYAM;PARIKH DIPESH;

    申请日2014-01-29

  • 分类号A61K31/137;A61K31/4015;A61K31/4196;A61P11;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:06

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