首页> 外国专利> isolated nucleic acid sequence, cell, methods for stimulating a cell-mediated immune response to a target cell or tissue population in a mammal, for providing antitumor immunity in a mammal, for treating a mammal having a disease, disorder or condition associated with high expression of a tumor antigen

isolated nucleic acid sequence, cell, methods for stimulating a cell-mediated immune response to a target cell or tissue population in a mammal, for providing antitumor immunity in a mammal, for treating a mammal having a disease, disorder or condition associated with high expression of a tumor antigen

机译:分离的核酸序列,细胞,在哺乳动物中刺激针对靶细胞或组织群体的细胞介导的免疫反应,在哺乳动物中提供抗肿瘤免疫力,治疗患有与高表达有关的疾病,病症或病状的哺乳动物的方法肿瘤抗原

摘要

1/1 summary “sequence of isolated nucleic acid, cell, methods to stimulate a cell-mediated immune response and a target cell population or tissue in a mammal to Provision of antitumor immunity in a mammal for treatment of a mammal having a disease, disorder or condition associated with a high expression of a tumor antigen is the present invention. Provides compositions and methods for the treatment of cancer in a human. The invention includes the administration of a genetically modified t-cell to express a chimeric antigen (car) receptor, a bispecific antibody, or a combination thereof in a patient. . The sugar and the specific antibody of the invention may comprise a human antibody, a humanized antibody, or antigen binding fragments thereof.
机译:1/1摘要“分离的核酸序列,细胞,刺激哺乳动物中细胞介导的免疫应答的方法和靶细胞群或组织对哺乳动物提供抗肿瘤免疫力以治疗患有疾病,病症的哺乳动物的序列与肿瘤抗原的高表达有关的疾病或病症是本发明。提供用于治疗人类癌症的组合物和方法。本发明包括给予患者基因改造的t细胞以表达嵌合抗原(car)受体,双特异性抗体或其组合。 。本发明的糖和特异性抗体可以包含人抗体,人源化抗体或其抗原结合片段。

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