Summary of the serogroup x meningococcal conjugate The invention provides a conjugate of a neisseria meningitidis serogroup x capsular polysaccharide and a carrier molecule. the conjugate is typically made by (a) oxidizing a primary hydroxyl group on the capsular polysaccharide to give an oxidized polysaccharide with an aldehyde group; and (b) coupling the oxidized polysaccharide to a carrier molecule via the aldehyde group, thereby giving the conjugate. the conjugate may be part of an immunogenic composition. Such a composition may comprise one or more additional antigens, in particular capsular polysaccharides of serogroups a, w135, c and y and conjugated forms thereof. The composition may be in an aqueous formulation. The composition is useful as a vaccine, for example to increase an immune response in a mammal. The invention also provides processes for the preparation of the conjugate.
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