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genetically modified nonhuman animal, genetically modified mammal, and method for making a nonhuman animal
genetically modified nonhuman animal, genetically modified mammal, and method for making a nonhuman animal
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机译：转基因的非人类动物，转基因的哺乳动物以及制造非人类动物的方法
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1/1 summary “genetically modified non-human animal, genetically modified mammal, and method for making a non-human animal” genetically modified non-human animals are provided that express a variable domain of the immunoglobulin comprising at least one histidine, wherein the at least one histidine is encoded by a substitution of a non-histidine codon in the germline of the animal with a histidine codon, or the insertion of a histidine codon. Of a histidine codon in a germline immunoglobulin nucleic acid sequence. immunoglobulin genes that comprise histidines in one or more cdrs, in an n-terminal region, and / or in a loop 4 region are also provided. variable immunoglobulin domains comprising one or more substituted histidines (e.g., histidine groups) in place of non-histidine non-antigen binding residues. non-human animals that are progeny of animals comprising modified heavy chain variable sites (segments v, d, j), modified light chain variable sites (segments v, j), and genes from rearranged germline light chain (sequences vj) are also provided. non-human animals that manufacture immunoglobulin domains that bind antigens in a ph-sensitive manner are provided.
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