首页> 外国专利> pharmaceutical composition, fusion protein, polynucleotide, vector, isolated cell, methods for producing a fusion protein, for treating or preventing a disease or condition, for diagnosing an individual's susceptibility to developing a disease or condition, for determining suitability of the individual to enter a drug classification experiment, and to identify an agent, use of a combination, and combination.

pharmaceutical composition, fusion protein, polynucleotide, vector, isolated cell, methods for producing a fusion protein, for treating or preventing a disease or condition, for diagnosing an individual's susceptibility to developing a disease or condition, for determining suitability of the individual to enter a drug classification experiment, and to identify an agent, use of a combination, and combination.

机译：药物组合物，融合蛋白，多核苷酸，载体，分离的细胞，产生融合蛋白的方法，用于治疗或预防疾病或病症，用于诊断个体发生疾病或病症的易感性，用于确定个体进入疾病的适宜性药物分类实验，并确定一种药物，组合的使用和组合。

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摘要

The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.

机译：本公开涉及可溶性CD52糖蛋白及其在治疗由效应T细胞调节的疾病中的用途，例如自身免疫性疾病，例如1型糖尿病。本公开还涉及包含可溶性糖蛋白的融合蛋白，表达高水平CD52的细胞，以及基于检测受试者中CD52表达水平的诊断方法。

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公开/公告号BR112014011758A2

专利类型
公开/公告日2017-05-09

原文格式PDF
申请/专利权人 THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;
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申请/专利号BR20141111758
发明设计人 ESTHER BANDALA SANCHEZ;JAMES DROMEY;LEONARD CHARLES HARRISON;MARYAM RASHIDI;YUXIA ZHANG;
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申请日2012-11-15
分类号A61K38/28;A61K38/10;A61P5/50;A61P37/06;C12N15/12;C12N15/86;G01N33/15;
国家 BR
入库时间 2022-08-21 13:40:33

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